Abstract
Purpose: To investigate the implication of eosinophilia in atopic dermatitis (AD).Methods: A total of 139 AD patients from The First Affiliated Hospital of Guangxi University of Chinese Medicine between February 2013 and May 2015, were involved in this study. Scoring atopic dermatitis (SCORAD) index was used to evaluate the skin lesions. The levels of IL-4, IL-5, IL-13, IL-17, INFgamma, IP-10, eotaxin and Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES), were determined with commercial enzyme-linked immunosorbent assay (ELISA) kits. Eosinophil counts were carried out by granulocyte count method. Correlation between SCORAD scores and levels of cytokines was analyzed using the Spearman correlation method.Results: SCORAD scores significantly increased in the eosinophil-positive group when compared to eosinophil-negative group (p < 0.05). Eosinophil counts correlated with SCORAD scores in the eosinophil-positive group (p < 0.05). INF-γ, IP-10 and RANTES levels were significantly higher in the eosinophil-positive group than in eosinophil- negative group, while IL-5, eotaxin and IL-17 levels significantly decreased in eosinophil-positive group (p < 0.05). In the eosinophil-positive group, IL-5, eotaxin and IL-17 levels positively correlated with SCORAD scores.Conclusion: Eosinophilia triggers lL-5, eotaxin and IL-17 changes and acts as a prognostic biomarker for atopic dermatitis. These findings may give further insights into the pathogenesis of AD.Keywords: Atopic dermatitis, Eosinophilia, SCORAD score, Biomarker, Cytokines
Highlights
Atopic dermatitis (AD) is a common chronic inflammatory and relapsing skin disease, which is always associated with food allergies and asthma [1]
Eosinophil counts correlated positively with Scoring atopic dermatitis (SCORAD) scores in eosinophil-positive group. These results suggest that eosinophil levels were associated with the SCORAD scores in the eosinophil-positive patients, indicating that eosinophil levels could reflect the level of skin injury in AD patients
INF-γ, IP-10 and RANTES levels were significantly increased in the eosinophil-positive group, no correlations were established between levels of INF-γ, IP-10 and RANTES, and SCORAD scores in the eosinophil-positive patients
Summary
Atopic dermatitis (AD) is a common chronic inflammatory and relapsing skin disease, which is always associated with food allergies and asthma [1]. It has been shown that chronic immune activation contributes to the pathophysiology of this EXPERIMENTAL common skin disease, and that eosinophils are frequently observed in AD patients [8]. Elevated blood eosinophil count is an important characteristic of AD patients [9]. Recent studies on activities of eosinophils revealed that they contain potent toxic proteins with the potential to mediate tissue damage [8-. Eosinophil counts and SCORAD scores were significantly lowered from "Half year" to "Two years" in the eosinophilnegative group (p < 0.05, Table 1). SCORAD scores were correlated with eosinophil counts in both groups. The results revealed that eosinophil counts were positively correlated with SCORAD scores in the eosinophil-positive group (Figure 2, p < 0.05). Correlation between SCORAD scores and levels of cytokines were analyzed using Spearman correlation method
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