Eosinopenia as a Marker of Sepsis in Intensive Care Unit Patients

Mesbah Uddin Ahmed,Iqbal Hossain Chowdhury,Suraiya Begum,Sheuly Ferdousi,A.N Nashimuddin Ahmed

doi:10.31579/2768-0487/038

Mesbah Uddin Ahmed, Iqbal Hossain Chowdhury + Show 3 more

Open Access

https://doi.org/10.31579/2768-0487/038

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Abstract

Sepsis is one of the most common cases of mortality and morbidity in the intensive care unit (ICU). This study was done to evaluate eonsinopenia as a marker of sepsis in intensive care unit patients. This cross sectional study was carried out in the Department of Clinical Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka from March 2012 to February 2013. Absolute Eosinophil Count (AEC) was done by automated cell counter and rechecked manually microscopically. In this study 74 suspected case of sepsis were enrolled from intensive care unit, BSMMU, Dhaka. Out of these patients 34 were included in the infection group and 40 in the non-infection group depending on blood culture report. The area under ROCcurve was 0.765 in current study. At the cutoff valve of AEC< 40 cell/cumm, the sensitivity and specificity of AEC for diagnosis of sepsis was 72.5% and 61.8% respectively. This present data revealed that decreased absolute eosinophil count was significantly associated with sepsis. So eosinopenia may be a reliable marker for early diagnosis of sepsis.

Highlights

Sepsis is one of most common causes of mortality and morbidity in the intensive care unit (Abidi et al, 2008)
This cross-sectional study was conducted at the Department of Clinical Pathology in collaboration with Department of Anesthesia, Analgesia and Intensive care Medicine and Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from March 2012 to February 2013. 74 suspected sepsis patients who were admitted in the Intensive Care Unit, BSMMU, Dhaka were enrolled for the study
Study population was divided into infection and non-infection group depending on blood culture reports. 34 patients were positive for culture who were included in infection group and 40 patients were negative for culture who were included in the non-infection group

Summary

Introduction

Sepsis is one of most common causes of mortality and morbidity in the intensive care unit (Abidi et al, 2008). Despite continuing advances in diagnosis and treatment, sepsis remains one of the important causes of higher mortality and morbidity. Diagnosis of sepsis plays an integral role in the morbidity and mortality of patients admitted to the intensive care unit (Rey et al, 2007). Eosinophil production is regulated by IL-3, IL-5 and granulocyte macrophage colony stimulating factor (GM-CSF). Eosinopenia during infection is enhanced by chemotactic substance such as C5a (Shaaban et al, 2010) This substance causes migration of eosinophils into the inflammatory site (Jagadesh et al, 2012). The definitive diagnosis of sepsis is made by a positive culture, which requires a minimum of Auctores Publishing – Volume 3(2)-038 www.auctoresonline.org

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