Abstract
Aminoglycosides have a well-known nephrotoxic potential in adults whereas renal side effects in neonates receiving these drugs are rare. Several studies have, however, shown that neonates receiving gentamicin or tobramycin invariably develop increases in the urinary activity of enzymes originating from renal tubular cells, notably alanine aminopep-tidase (AAP) and TV-acetyl-beta-D-glucosaminidase (NAG).14 Although the clinical importance of enzymuria remains to be determined, it has been considered to be an early sign of renal damage.1,5,6 Because of the unique antibacterial spectrum of the aminoglycosides it has not been possible until recently to study enzymuria in neonates receiving aminoglycosides with a control group receiving other antibacterial agents. With the introduction of beta-lactam antibiotics with improved activity against Gram-negative rods this has now become possible. The aim of the present study was to compare the urinary activities of AAP and NAG in neonates during treatment with tobramycin or ceftazidime, a new beta-lactam antibiotic with a broad antibacterial spectrum.
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