Abstract
This chapter discusses enzymological pattern in guinea pig's blood in experimental T. cruzi as a test of hepatocytic damage. The sorbitol dehydrogenase, phosphofructoaldolases, icocitrate dehydrogenase, leucine aminopeptidase, and maliate dehydrogenase enzymes photo- were assayed and spectrophotocolorimetricaly in control guinea pig's blood as well as in a group inoculated with T. cruzi. In the control group, citrated noninfective blood was injected subcutaneously. The examinations were made in the blood disproteined beforehand by percloric acid, on the 6th and 10th day after the experiment had begun. It was observed that the specificity of the increasing enzymes SDH and FFA and the others that was not so specific but of supplementary value for the diagnosis, as ISDH, LAP and MDH, indicates that there were hepatocytic alterations in the first stage of the chagasic disease. The collected results showed a significant increase in the serum values of the enzymes studied in the acute period of the experimental T. cruzi in guinea pigs.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
