Abstract
Enzymic NADPH-dependent systems of lipid peroxidation and chlorpromazine metabolism were shown to be localized in rat and human brain microsomal fractions (BMF). Hydroxy-derivatives of chlorpromazine [7-hydroxychlorpromazine (7-OH)] formed as a result of enzymic NADPH-dependent metabolism possess antioxidant action and inhibit enzymic peroxidation of lipids (POL) in brain microsomes. The properties of enzymic NADPH-dependent oxygenase systems in the membranes of the endoplasmic reticulum of the liver and BMF are compared.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.