Abstract
Enzymic NADPH-dependent systems of lipid peroxidation and chlorpromazine metabolism were shown to be localized in rat and human brain microsomal fractions (BMF). Hydroxy-derivatives of chlorpromazine [7-hydroxychlorpromazine (7-OH)] formed as a result of enzymic NADPH-dependent metabolism possess antioxidant action and inhibit enzymic peroxidation of lipids (POL) in brain microsomes. The properties of enzymic NADPH-dependent oxygenase systems in the membranes of the endoplasmic reticulum of the liver and BMF are compared.
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