Abstract
A new transmethylating enzyme system in mammalian tissues, catalyzing methyl transfer from S-adenosylmethionine to sulfhydryl compounds, has been studied. A series of “nonphysiological” sulfhydryl compounds (BAL, mercaptoethanol, O-methyl-mercaptoethanol, mercaptoacetic acid, β-mercaptoproprionic acid, methymercaptan and hydrogen sulfide) have been found to act as methyl accepting substrates, whereas “physiological” sulfhydryl compounds (homocysteine, cysteine and glutathione) are inactive. With S-adenosylethionine a “transethylation” is found to take place. The transmethylating enzyme system is present in the microsome fraction of several tissues of the rat and in the liver of 6 mammalian species investigated.
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