Abstract
The production of large quantities of paclitaxel for use as an anticancer treatment has been a difficult problem because of the low concentration of the compound in yew trees (Taxus sp.) and its occurrence as part of a mixture of other taxanes. 7-Xylosyltaxanes are major components of the mixture found in the bark of the Pacific yew (Taxus brevifolia). A bacterial strain isolated from soil and identified as a Moraxella sp. was able to remove the xylosyl group from 7-xylosylpaclitaxel, 7-xylosyl-10-deacetylpaclitaxel, 7-xylosylbaccatin III and 7-xylosyl-10-deacetylbaccatin III, thereby making the xylosyltaxanes available as sources of 10-deacetylbaccatin III for semisynthesis of paclitaxel. The activity was located in both the soluble and particulate fractions of the cell.
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