Abstract
1. 1. Data have been presented comparing the activities of anaerobic glycolysis, the tricarboxylic acid cycle, pyruvate oxidation, succinic dehydrogenase, glutamic dehydrogenase, and aspartic-glutamic transaminase in tissues of normal and alloxan-diabetic rats. 2. 2. Of the above enzyme systems, all except glutamic dehydrogenase were found to be increased significantly in the livers of alloxan-diabetic rats. 3. 3. The succinic dehydrogenase activities of corpora lutea of lactation, brain, and kidney of diabetic rats were normal. Likewise, the activity of aspartic-glutamic transaminase in kidney and heart was unaltered in the diabetic animal. 4. 4. The increases in activity of the various enzymes in the liver of the diabetic rat are discussed with regard to changes in metabolism occurring in diabetes.
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