Abstract
Thymidine phosphorylase (E.C. 2.4.2.4) (TP), also described as the angiogenic platelet-derived endothelial cell growth factor (PD-ECGF) (, , , ), is a homodimeric enzyme with a monomeric molecular mass of about 55 kDa (,) that phosphorolytically cleaves thymidine to yield thymine and deoxyribose-1-phosphate (dR-1-P) (,). TP is expressed in various human cells and tissues and plays a role in plasma thymidine homeostasis (, , ). The levels of expression in different human tissues can vary up to 15-fold (). Moreover, TP levels are increased in several types of malignant tumors when compared to the non-neoplastic regions of these tissues () and also in the plasma from tumor-bearing animals and cancer patients ().
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