Abstract
Ligation or transsection of the common bile duct in rats was followed by a histochemically demonstrated increase of alkaline phosphatase reaction in the liver from the 1st postoperative day, and centrolobular loss of canalicular adenosine triphosphatase reaction from the 5th day. The peripheral canaliculi appeared thickened and irregular. The acid phosphatase reaction was increased in hepatocytes and Kupffer cells. Gamma‐glutamyl transpeptidase became positive in an increased number of bile ducts and ductules. With Nitro‐BT as substrate the formazan products of succinic dehydrogenase and monoamine oxidase changed from regular, coarse sinusoidal granules into irregular masses along the sinusoids and the finely granular hepatocytic products became reduced. Serum alkaline phosphatase and gamma‐glutamyl transpeptidase reached a maximum at 1 day and 2 weeks, respectively, after operation.
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