ENZYME INHIBITORS OF MICROBIAL ORIGIN

Abstract

This chapter explains the enzyme inhibitors of microbial origin. The study of antibiotics, finds new compounds with interesting activities, studying their chemistry, biosynthesis and, mechanism of action. It has been proved that a characteristic part of biosynthesis of an antibiotic is controlled by genetic material on a plasmid, that is, genetic material in a DNA different from the cell genome. The ability of microorganisms to produce secondary metabolites with various structures is due to a great variety of plasmids. Based on this ability of microorganisms, and for the purpose of exploiting a new research area, the screening of enzyme inhibitors has been initiated found in microbial culture filtrates. The enzyme inhibitors are useful in the analysis of biological functions and disease processes and have potential utility in the treatment of diseases. Compared with the macromolecular nature of enzyme inhibitors obtained from animal and plant tissues, the inhibitors found in microbial culture filtrates are small molecular compounds, and rapidly elucidate their structures and study structure activity relationships and their metabolism.