Abstract
Human interferon-β (HuIFN-β) titer after intransal administration was determined by enzyme immunoassay (EIA), substituting for bioassay. The intranasal absorption was linearly related to HuIFN-β dose. Compared with intravenous administration, the mean bioavailability of intranasal HuIFN-β was 3%. The effects of several excipients, human serum albumin (HSA), polyethylene glycol, diethylaminoethyl-dextran, carboxy polymethylene, α-cyclodextrin and cholesteryl stearate, on the absorption of HuIFN-β were examined with the powder dosage form. Among these excipients, HSA and α-cyclodextrin gave the highest HuIFN-β concentrations in plasma. The area under the plasma concentration-time curve (AUC) decreased as the molecular weight of excipients was increased.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
