Abstract
The activity of a number of oxidoreductases in carcinomas of the breast, colon and rectum was studied enzyme histochemically and compared with the activity in adjacent normal epithelium. In both mammary and colonic carcinoma, the activity of the NADPH-tetrazolium reductase system was found to be elevated. In colonic and rectal carcinoma there seems to be a strong tendency of the catabolic enzymes (NADH-tetrazolium reductase, succinic acid dehydrogenase, and α-glycerophosphate oxidase) towards decreased activity. Breast cancers, however, have a tendency toward an elevated catabolism.
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