Abstract
Enzymes (endonucleases) are coupled to constitutional dynamic networks to stimulate the selection of a constituent and cascaded emergence of a new network. This is exemplified with the EcoRI-dictated depletion of a network and selection of a constituent that activates the cascaded emergence of a new network. The new network is further depleted by HindIII to a selected constituent that can be coupled to the cascaded emergence of a dynamic network. In addition, upon subjecting a [3 × 3] constitutional dynamic network to endonucleases EcoRI and HindIII, the programmed hierarchical selection of [2 × 2] constitutional dynamic networks followed by the biocatalytic selection of a constituent for the subsequent emergence of new networks is demonstrated.
Highlights
Enzymes are coupled to constitutional dynamic networks to stimulate the selection of a constituent and cascaded emergence of a new network
Constitutional dynamic networks (CDNs) play key functions in controlling intracellular transformations,[1−6] and substantial research efforts are directed to assemble synthetic systems mimicking these processes.[7−10] The simplest CDN consists of four interequilibrated constituents AA′, AB′, BA′, and BB′
We introduce an unprecedented concept in nucleic-acid-based constitutional dynamic networks, whereby we couple enzymes to constituent modules associated with CDNs as a means to control the hierarchical selection and cascaded emergence of networks
Summary
Enzymes (endonucleases) are coupled to constitutional dynamic networks to stimulate the selection of a constituent and cascaded emergence of a new network.
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