Abstract
The highly enantioselective ( E >200) kinetic resolution of (±)-ethyl cis-(±)- 4 and trans-1-( tert-butoxycarbonyl)-4-hydroxypiperidine-3-carboxylate (±)- 5 was achieved by Pseudomonas fluorescens lipase-catalyzed asymmetric acylation with vinyl acetate in diisopropyl ether at room temperature. Candida antarctica lipase A-catalyzed asymmetric acylation of (±)-ethyl cis-1-benzyl-3-hydroxypiperidine-4-carboxylate (±)- 11 was performed with vinyl propanoate in diisopropyl ether at 3 °C, with good enantioselectivity ( E = 75).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
