Abstract
Enzyme Catalytic Power Minireview Series
Highlights
One of the great remaining unsolved questions in biological chemistry is the nature of enzyme catalysis
Enzyme catalytic efficiency is still hotly debated with new ideas or viewpoints emerging and old ideas being repackaged in an attempt to understand these biocatalysts
How does an enzyme enhance the rate of a chemical reaction by 108- or 1013- or 1018-fold? What are the general principles involved that all enzymes utilize? For a long time enzyme chemists have realized that general physical chemical principles should accommodate understanding without needing to invoke any enzymatic “secrets.” The pathway of changes in chemical bonding, the kinetic order of addition of substrates, the rates of various steps, and the three-dimensional structural aspects of the protein surface are known for many, many enzymes
Summary
One of the great remaining unsolved questions in biological chemistry is the nature of enzyme catalysis. Enzyme catalytic efficiency is still hotly debated with new ideas or viewpoints emerging and old ideas being repackaged in an attempt to understand these biocatalysts.
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