Abstract
Enzyme Activities of Liver Function (Bio-makers) in Sickle Cell Anaemic Patients Attending Sickle Cell Anaemic Centre, Benin City, Edo State, Nigeria
Highlights
Sickle-cell anemia is a hereditary blood disease caused by a defective gene that produces an abnormal form of hemoglobin, the component of red blood cells responsible for transporting oxygen from the lungs to the tissues
This study aims to assess the enzyme activities of serum Glutamyl transpeptidase (GGT), Alanine transaminase (ALT), Aspartate transaminase (AST) and levels of total protein and albumin in sickle cell anaemia
The results of liver function tests in patients with sickle cell disease when compared with controls showed a statistical significant difference in the enzyme activities of serum glutamyl transpeptidase (GGT), transaminases (Alanine Transaminase and Aspartate transaminase), levels of total protein and albumin and its conjugated fraction (P < 0.05)
Summary
Sickle-cell anemia is a hereditary blood disease caused by a defective gene that produces an abnormal form of hemoglobin, the component of red blood cells responsible for transporting oxygen from the lungs to the tissues. Bin S, distorts red blood cells after they release oxygen in the tissues These distorted cells are called sickled cells [1]. Sickle cell disease affects millions of people throughout the world and is common among those whose ancestors came from sub-Saharan Africa, South America, the Caribbean, Central America, Saudi Arabia, India and Mediterranean countries (such as Turkey, Greece, and Italy) [2]. It is a multi systemic disorder affecting about 1 in 500 African Americans. 300,000 infants are born with it annually [3]
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