Abstract
Alanine aminotransferase activity decreased gradually in marginal and regenerating epithelium during the first 4 days of wound healing. A decreasing gradient of alanine aminotransferase activity was observed from the marginal epithelium to the migrating epithelial tip; the actively migrating epithelial tip exhibited only 10% of normal activity. In contrast to alanine aminotransferase activity, aspartate aminotransferase activity increased slightly and did not exhibit a significant differential distribution gradient within regenerating epithelium. The epithelium at the wound margin exhibited three-fold increases in glucose-6-phosphate dehydrogenase and malic enzyme activities, little alteration in 6-phosphogluconate dehydrogenase activity, and a 30% decrease in isocitrate dehydrogenase activity, together with an increased NADPH concentration. Regenerating epithelium demonstrated a five-fold increase in glucose-6-phosphate dehydrogenase and malic enzyme activities and a 60% increase in 6-phosphogluconate dehydrogenase and isocitrate dehydrogenase activities, together with an elevated level of NADPH concentration.
Published Version
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