Abstract
Histamine in the brain shows many neurochemical characteristics resembling the catecholamines and serotonin (Snyder and Taylor, 1972). It is distributed unevenly throughout the brain with the highest concentration occurring in selected hypothalamic nuclei. Subcellular fractionation studies reveal that a major portion of the histamine content in adult rat brain is localized to nerve terminals. Specific enzymes are present in the brain for the synthesis and metabolism of histamine, and its release upon depolarization of brain slices has been demonstrated (Snyder and Taylor, 1972). However, the role of histamine in the brain is still controversial. This is due mainly to the methodological difficulties in the study of histamine in brain tissue.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.