Abstract
Histamine in the brain shows many neurochemical characteristics resembling the catecholamines and serotonin (Snyder and Taylor, 1972). It is distributed unevenly throughout the brain with the highest concentration occurring in selected hypothalamic nuclei. Subcellular fractionation studies reveal that a major portion of the histamine content in adult rat brain is localized to nerve terminals. Specific enzymes are present in the brain for the synthesis and metabolism of histamine, and its release upon depolarization of brain slices has been demonstrated (Snyder and Taylor, 1972). However, the role of histamine in the brain is still controversial. This is due mainly to the methodological difficulties in the study of histamine in brain tissue.
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