Abstract
AbstractWe have synthesized β‐O‐D‐galactopyranosyl‐(1,4′)‐2′‐[18F]fluoro‐2′‐deoxy‐D‐glucopyranose (2′‐[18F]fluorodeoxylactose, 18FDL) using an enzymatic method starting from 18FDG in order to evaluate this compound with regard to its usefulness for in vivo visualization of the expression of the LacZ gene. Incubation of 18FDL with β‐galactosidase results in the formation of 18FDG. Biodistribution studies in normal mice showed that 18FDL is cleared by urinary excretion and is not retained in any tissue. Biodistribution in Rosa‐26 mice is identical to the biodistribution in normal mice, suggesting that 18FDL is not able to cross the cell membrane. Copyright © 2001 John Wiley & Sons, Ltd.
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