Abstract
( R)-2-Tetralol ( R) - 2a, ( R)-5-hydroxy-2-tetralol ( R) - 2b and ( R)-8-hydroxy-2-tetralol ( R)- 2c, which are key intermediates in the synthesis of pharmacologically active 2-aminotetralins 3, were prepared in moderate to very high enantiomeric excess (up to 99% ee) by enzymatic resolution of the corresponding racemic butyrates rac- 1a, rac- 1b and rac- 1c, respectively, using lipases immobilized on octyl agarose. This methodology is an alternative to the microbial reduction of 2-tetralones.
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