Enzymatic racemization of alcohols and amines: An approach for bi-enzymatic dynamic kinetic resolution.

Abstract

Racemization is the key step to turn a kinetic resolution (KR), which suffers from the well-known drawback of being limited to a maximum yield of 50% with high enantiopurity, into a dynamic kinetic resolution (DKR) process. Enzyme-based racemization of enantiopure alcohols and amines has gained significant interest in recent years. This review covers recent advances in enzyme-based racemization approaches and their potential applications in bi-enzymatic DKR.