Abstract

AbstractA wide range of novel, enantiomerically pure 4‐chloro(amino)pyridine derivatives has been synthesised through a chemoenzymatic approach, Candida antarctica lipase B (CAL‐B) and Pseudomonas cepacia lipase (PSL) being found to be excellent biocatalysts for the preparation of new and interesting amines and amides in enantiomerically pure form through enzymatic aminolysis reactions. A study of the enzymatic reactivity of CAL‐B and PSL has been done in the resolution of a library of amine structures in an attempt to rationalise the experimental results obtained in their enzymatic kinetic resolution mediated by lipases.

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