Abstract
The metabolism of two tertiary aromatic phosphines, 3-dimethylaminopropyldiphenylphosphine (a CNS depressant) and diphenylmethylphosphine, was studied. These compounds were incubated with subcellular fractions of rat liver homogenates and found to be enzymatically converted to the corresponding phosphine oxides; the aminophosphine gave rise to an N, P-dioxide. Enzymatic activity was localized in the microsomal fraction and shown to be associated with the cytochrome P-450 mixed function oxidases. The substrates were also found to undergo a facile non-enzymatic reaction with thiols, a factor which portends their possible chronic toxicity.
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