Abstract
Ionic liquids (ILs) have attracted growing interest as alternative reaction media for enzyme-catalyzed transformations because of their unique properties as green solvents, opening up news opportunities in the field of pharmaceutical synthesis. Additionally, enzymatic transformations in ILs/scCO 2 biphasic systems have been described as an interesting way of carrying out clean synthetic processes whereby enzyme molecules are immobilized into the IL phase, while substrates/products are transported by the scCO 2 phase. Several ILs based on alkyl-imidazolium cations and associated with different anions, ([PF 6] , [BF 4] and [NTf 2 ]), have been assayed for the Candida antarctica lipase B (CALB)-catalyzed resolution of the analgesic rac-ketoprofen by esterification with different 1-alkanols. A membrane reactor working with both IL and supercritical carbon dioxide (scCO 2 ) phases has been applied for separation of R-ketoprofen ester products.
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