Abstract
In the present work a simple laboratory procedure for the synthesis of (R)-3-Fluorolactic Methyl Ester(1) is described. A coupled enzymatic system formed by rabbit muscle l-lactate dehydrogenase (l-LDH), horse liver alcohol dehydrogenase (HLADH), fluoropyruvic acid sodium salt, NAD+ and cis-1,2-bis(hydroxymethyl)cyclohexane were found to be very effective for production of (1) in 80% overal yield and ee > 99%.
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