Abstract
Abstract In situ real-time electroanalysis of neurochemical concentrations offers rich information for exploring the spatiotemporal heterogeneity of molecular events in the nervous system. Biosensors with enzyme-modified sensing interfaces are well suited for measuring neurologically important but electroinactive species, greatly broadening the range of electrochemically detectable analytes. Minimally invasive micro/nanoelectrodes bearing enzymatically functional layers are used to fulfill the spatiotemporal requirements for in situ neurochemical studies at various neuronal levels as discussed in this minireview. Current achievements on nanoelectrode biosensors for intracellular analysis and microelectrode biosensors for single-cell and in vivo analysis are highlighted to enlighten emerging trends in this realm, and views of prospective enzymatic biosensors for neurochemical analysis are provided in the end.
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