Abstract
The chemoenzymatic dynamic kinetic resolution (DKR) protocol combines the enzyme‐catalyzed resolution of a racemic substrate with the in situ racemization of the less reactive enantiomer, thus, producing optically active products in up to quantitative yield. This is of great interest for the pharmaceutical industry because by using this methodology, some of the serious drawbacks associated with drug production can be solved. Enzymatic DKRs are environmentally friendly processes that could help reduce cost and waste. The first and principal section of this chapter addresses the usefulness of hydrolases (particularly lipases) for the DKR of alcohols, diols, amines, and esters. In the following sections, DKRs with other enzymes such as haloalcohol dehalogenase, dehydrogenases, transaminases, and Baeyer‐Villiger monooxygenases are considered.
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