Enzymatic deficiency in monocytes from patients with chronic granulomatous disease.

Abstract

Chronic granulomatous disease (CGD) is by convention defined as a disorder involving a high susceptibility to bacterial infection related to the inability of the patient’s neutrophils to increase oxygen consumption, despite normal phagocytosis and normal degranulationl,2. CGD appears to be heterogeneous; most cases show an inherihance pattern typical of X-linkage, but the remainder are of non X-linked variety2. CGD heterogeneity has been further suggested by the lack of membrane components in some CGD patients as kx Antigen in neutrophils or red blood cells3, and b-like cytochrome in neutrophils4,5. In two different patients with CGD it has been possible to induce the oxidative burst, with stimuli other than those used in standard analysis procedure6,7.