Abstract
AIM: To study on the expression characteristics of ChAT, GAD65 and PKC enzymatic activities and their clinicopathological significance in the tissues of chronic pancreatitis and pancreatic carcinoma. METHODS: The enzymatic activities of ChAT, GAD65 and PKC were detected by immunohistochemical method of avidin-biotin complex on formalin-fixed and routine paraffinembedded sections of specimens of chronic pancreatitis (n =10) and pancreatic carcinoma (n =47). RESULTS: The positive rate and the score of ChAT, GAD65 and PKC were significantly lower in 10 cases of chronic pancreatitis than that of pancreatic carcinoma (ChAT, 0 % vs 48.9 % , 0.2±0.4 vs 2.2±1.4; GAD65, 10.0 % vs 55.3 %, 0.6±0.9 vs 2.2±1.2; PKC, 10.0 % vs 57.4 %, 0.6±0.9 vs 2.1±1.6). The score of ChAT was significantly higher in well-differentiated adenocarcinoma than that of poorlydifferentiated adenocarcinoma (P <0.05). The positive rate and the score of GAD65 or PKC were significantly lower (GAD65, P <0.05; PKC, P <0.01) in cases of well-differentiated adenocarcinoma than in cases of poorly-differentiated. No difference was found for the enzyme expressions and the clinicopathological characteristics among different sex, age, with or without metastasis of pancreatic carcinoma. A highly positive correlation was found between the scores of GAD65 and PKC in pancreatic carcinoma.
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