Environmentally Friendly Synthesis of Gelatin Hydrogel Nanoparticles for Gastric Cancer Treatment, Bisphenol A Sensing and Nursing Applications: Fabrication, Characterization and ANN Modeling

Abstract

This study presents a dual application approach for the environmentally friendly synthesis of gelatin hydrogel nanoparticles with potential applications in gastric cancer treatment, bisphenol A (BPA) sensing, and nursing. Gelatin hydrogel nanoparticles were synthesized using a green and freeze-drying method, avoiding the use of toxic chemicals and solvents. The nanoparticles showed excellent biocompatibility and promising potential for drug delivery system (DDS) in gastric cancer treatment. The controlled release of anticancer drugs from the gelatin nanoparticles was showed, highlighting their potential in targeted therapy. Additionally, the gelatin hydrogel nanoparticles were explored for BPA sensing. BPA is a widely used chemical known for its adverse effects on human health. The gelatin nanoparticles showed high selectivity and sensitivity towards BPA detection, making them suitable for environmental monitoring and health applications using scanning electron microscope (SEM). Also, in this study, an artificial neural network (ANN) was used to estimate the release of docetaxel (%) at 72 hours, the release of paclitaxel (%) at 72 hours, tensile strength with sample (wt%), and porosity (%) in broader ranges than the experimental samples. The environmentally friendly synthesis of gelatin hydrogel nanoparticles presented in this study offers a versatile platform with dual applications in gastric cancer treatment and sensing of harmful chemicals. The obtained results show the potential of these nanoparticles for innovative therapeutic and diagnostic strategies in healthcare and environmental monitoring. The study showed the development of sustainable and multifunctional nanomaterials for various biomedical applications. The modeling of the neural network predictions shows that increasing the sample (wt%) and porosity (%) leads to an increase in the release of docetaxel (%) at 72 hours, the release of paclitaxel (%) at 72 hours, and tensile strength. As porosity decreases, the release of docetaxel increases, and the release of paclitaxel and tensile strength also increase. Additionally, the prediction errors of the ANN in this study were evaluated using linear regression, showing acceptable error rates compared to the target results obtained from the experimental tests.