Abstract
Recyclable CuO nanoparticles were successfully employed to catalyze the microwave-assisted (3+2) cycloaddition reaction between nitriles and NaN3 to efficiently synthesize 5-substituted 1H-tetrazoles. The salient features associated with this protocol are its cost effectiveness, rapid synthesis, stability, reusability, mild reaction conditions without any additives, high tolerance to various functional groups, and excellent yields under microwave irradiation. This environmentally friendly, microwave-assisted, nanoparticle-catalyzed synthetic methodology is seen as an alternative to conventional procedures that involve Lewis acid catalysts and a simple operation to the privileged scaffold.
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