Environmental toxicants and autoimmunity

Abstract

Autoimmunity is a condition where structural and functional damage happen by the immunologically competent cells or antibodies to self-antigens . Autoimmune diseases result from destruction of self – proteins, cells, organs by autoantibodies or self- reactive T cells. There are certain factors that can trigger the autoimmunity, like – Genetic factors, Toxic chemicals (Environmental factors), Viral, Hormonal, stress and neurochemicals. In this review there are several aspects that come across the fact that Environmental toxicants has important contribution in autoimmunity. Many pesticides, and Hg also has a definite role in autoimmunity. This review paper provides us elaborate predisposition of environmental toxicants to autoimmunity. This review paper is also consists of little discussion of genetic factors and how they interlinked to autoimmunity.