Environmental risk assessment of the anthelmintic albendazole in Eastern Africa, based on a systematic review.

Abstract

This study performs an environmental risk assessment (ERA) of the anthelmintic medicine albendazole (ABZ) in the eastern African region. A systematic literature search strategy was applied to obtain quantitative information on the physicochemical characteristics, the metabolization-fate, the ecotoxicity and the environmental occurrence in different countries worldwide serving as model regions. In addition, insilico tools were employed to obtain data on physicochemical characteristics and toxic hazards of ABZ and its metabolites. Moreover, ERA models were used to predict environmental concentrations in different compartments and compare them with the measured environmental concentrations. Finally, the environmental risk of ABZ in the eastern Africa was estimated by calculating the risk quotient (RQ), and its uncertainty estimated by Monte Carlo simulation. The predicted environmental concentrations of ABZ in surface water in the model region based on consumption (1.6-267ng/L) were within the range of values obtained from the measured environmental concentrations of the same region (0.05-101,000ng/L). Using these models with adapted input variables for eastern Africa, the predicted surface water concentration in that region was 19,600±150ng/L (95% CI). The calculated soil concentrations of ABZ in the model regions and the eastern Africa were found to be 0.057±0.0μg/kg and 0.022±0.0μg/kg, respectively. The environmental risk expressed as risk quotient of ABZ in eastern Africa estimated for the aquatic compartment (146±1) indicated a significant environmental risk calling on appropriate actions from the competent authorities to reduce this risk in this region.