Abstract
The incidence of obesity has reached an all-time high, and this increase is observed worldwide. There is a growing need to understand all the factors that contribute to obesity to effectively treat and prevent it and associated comorbidities. The obesogen hypothesis proposes that there are chemicals in our environment termed obesogens that can affect individual susceptibility to obesity and thus help explain the recent large increases in obesity. This review discusses current advances in our understanding of how obesogens act to affect health and obesity susceptibility. Newly discovered obesogens and potential obesogens are discussed, together with future directions for research that may help to reduce the impact of these pervasive chemicals.
Highlights
Obesity is a pandemic that has reached worldwide proportions, affecting essentially every country [1]
M approximately 4 million deaths worldwide between 1980 and 2015 [3]. d There is an urgent need to understand all of the factors contributing to te obesity to best implement effective prevention and treatment p approaches that have so far proved elusive. ce The obesogen hypothesis AcThe predominant medical explanation continues to be that obesity is the result of a simple imbalance between excessive calorie intake and insufficient energy expenditure – the energy balance or “calories in, calories out” model
Genetics is widely believed to be associated with obesity; known gene t variants can only explain 2.7% of the individual variation in body mass index nu (BMI) [7]. ip the two most commonly given explanations - genetics and cr energy balance - cannot fully explain the substantial increases in s obesity incidence observed worldwide. nu Multiple environmental factors can impact obesity susceptibility a
Summary
Downloaded from https://academic.oup.com/endo/advance-article-abstract/doi/10.1210/endocr/bqaa024/5739626 by University of California, Irvine user on 19 February 2020 Environmental obesogens and their impact on susceptibility to obesity: new mechanisms and chemicals Riann Jenay Egusquiza1,2 and Bruce Blumberg1,2,3,4 ipt 1Department of Developmental and Cell Biology, University of r California, Irvine, CA 92697-2300 sc 2Department of Pharmaceutical Sciences, University of California, u Irvine, CA an 3Department of Biomedical Engineering, University of California, Irvine, CA
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
