Environmental enrichment restores impaired spatial memory and synaptic plasticity in prenatally stress exposed rats: The role of GABAergic neurotransmission.

Abstract

Evidence shows that prenatal stress negatively affects cognitive functions and activity of neuronal circuits in postnatal age. Environmental enrichment counteracts deficits induced by early life stress. We examined if behavioural function and synaptic plasticity are sensitive to prenatal stress and, how much environmental enrichment and GABAergic system impact these phenomena. Animals were exposed to noise stress during the third trimester of foetal life. Groups of the stressed animals remained intact (S-SH) or received enrichment (S-EE) from postnatal day 22 for one month. Also, two groups received either saline (S-SH-S) or bicuculline (S-SH-B). One enriched group received muscimol (S-EE-M). The control groups were intact (C-SH), enriched (C-EE), or received bicuculline (C-SH-B) or saline (C-SH-S). We assessed learning and memory and, hippocampal long-term potentiation (LTP). Serum corticosterone levels were detected as a measure of stress condition. We found that stress reduced spatial performance and suppressed LTP in the S-SH animals. Postnatal enrichment restored both spatial learning and memory and synaptic plasticity in the S-EE rats. GABAergic antagonism strengthens maze performance and LTP induction in the S-SH-B group. However, muscimol prevented the positive effects of enrichment in the S-EE-M animals. Environmental enrichment and GABAergic modulation may improve disrupted spatial performance and synaptic plasticity.