Abstract
Developmental processes and the effects of toxic agents in the environment that alter CNS growth and maturation are reviewed by a researcher in the Department of OB/GYN, University of Rochester Medical Center, Rochester, NY.
Highlights
Developmental processes and the effects of toxic agents in the environment that alter CNS growth and maturation are reviewed by a researcher in the Department of OB/GYN, University of Rochester Medical Center, Rochester, NY
Valproic acid (VPA) exposure is linked to neural tube defects, developmental delays, and possibly autism
Lack of normal Reelin protein underlies lissencephaly and cerebellar hypoplasia, and increased Reelin expression is reported in polymicrogyria
Summary
Developmental processes and the effects of toxic agents in the environment that alter CNS growth and maturation are reviewed by a researcher in the Department of OB/GYN, University of Rochester Medical Center, Rochester, NY. Processes discussed include: establishment of neuron numbers, migration of neurons, connections, neurotransmitter activity, receptor numbers, myelin deposition, and postnatal neurogenesis. The neuroteratological effects of toxic chemicals (eg lead, methylmercury, alcohol) and new drugs (antiepileptic drugs) have been studied in relation to prenatal and early postnatal life, but little attention is given to toxins in later childhood and adolescence. Valproic acid (VPA) exposure is linked to neural tube defects, developmental delays, and possibly autism.
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