Environmental and Convenient Construction Strategy to Obtained New Supreme Series of Fused 1,2,4-Triazalo System Incorporating N-Acetyl Quanazole

Abstract

The presentation goal is to develop new procedures for regioselective synthesis of unusual series of heterocyclic compounds (2-8) derived from N-acetyl guanazole (1) which received a great deal of attention due to it's unique properties. N-acetyl guaunazole used as active precursor to obtained two type of fused 1,2,4-triazole system. The first one including grinding for (1 min.) of a mixture consist of N-acetyl guanazole , malononitrile and substituted benzaldehlyde through direct one-pot multicomponent reaction to achieve a new series of 1,2,4-trazolo[1,5-a,4,3-a]bispyrimidine (2-7). Whereas, the second one involved firstly the conversion of N-acetyl gluanazole to the corresponding Schiff base (8-13) accelerated by microwave irradiation (MWI) for few minutes, then they will underwent intercyclization reaction with phenyl isothiocynate and also acceclerated by grinding then by microwave irradiation to afford 1,2,4-triazolo[1,5-a,4,3-a] bistriazine (14-18).