Abstract
An efficient synthesis of 2-[(5 / -(substituted phenyl)-1 / -phenyl) pyrazolyl] pyrroles III (a-m) starting from 2-acetyl pyrrole I and 2-[substituted benz-1/(propene-1//-one)] Pyrroles II (a-m), in the presence of phenyl hydrazine, 2-[(5 / -(4 // -substituted phenyl)-1 / -phenyl) pyrazolyl] pyrroles III (a-m) has been synthesized in microwave oven for the first time. On comparing with the classical methods, this method has advantages such as shorter reaction time, better yield, simple workup and environmental acceptability.
Highlights
In recent years the pollution free organic reaction and assisted by microwaves in particular have been gained special attention[1,2]
As Microwave induced Organic Reaction Enhancement (MORE) chemistry[5,6] allows reaction to occur on a preparative scale in open vessels under solvent free conditions which avoids the risk of high pressures and explosions[7,8] microwave activation rather than conventional heating is preferred as solid supports are rather poor thermal conductors but strong microwave absorbents[9]
One reaction is that the use of microwave activation in organic synthesis can increase the purity of the resulting products, enhance the chemical yield and shorten the reaction time
Summary
In recent years the pollution free organic reaction and assisted by microwaves in particular have been gained special attention[1,2]. The other reason is that solvent free reaction avoids organic solvents during the reaction in organic synthesis, lead to a clean, efficient and economical technology[10] It has many advantages such as high efficiency and selectivity, easy separation and purification, mild reaction conditions and environmental acceptability[11], further the reactions are generally faster and the products obtained are of high purity[12], for increase the efficiency of microwave reaction number of inorganic solid supports like, alumina, silica gel, montmorillonite K10 clay, etc are used as catalyst and as energy transfer, medium that devoid the hazards of solution phase reactions. Nitrogen containing heterocyclic compounds[17] like pyrroles and pyrazoles have received considerable attention in recent years due to their biological activities like anti-inflammatory, anlagen, anticonvulsant and antidiabetic[18]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
