Entropy, complexity, and maturity in children's neural responses to naturalistic video lessons

Abstract

Temporal characteristics of neural signals are often overlooked in traditional fMRI developmental studies but are critical to studying brain functions in ecologically valid settings. In the present study, we explore the temporal properties of children's neural responses during naturalistic mathematics and grammar tasks. To do so, we introduce a novel measure in developmental fMRI: neural entropy, which indicates temporal complexity of BOLD signals. We show that temporal patterns of neural activity have lower complexity and greater variability in children than in adults in the association cortex but not in the sensory-motor cortex. We also show that neural entropy is associated with both child-adult similarity in functional connectivity and neural synchrony, and that neural entropy increases with the size of functionally connected networks in the association cortex. In addition, neural entropy increases with functional maturity (i.e., child-adult neural synchrony) in content-specific regions. These exploratory findings suggest the hypothesis that neural entropy indexes the increasing breadth and diversity of neural processes available to children for analyzing mathematical information over development.