Abstract
Five genotypes (1a, 1b, 2a, 2b, and 3) have been reported for GB virus C or hepatitis G virus (GBV-C/HGV) based on its 5′ terminal nucleotide sequence, but it is yet unseen whether the use of such a short subgenomic sequence is truly effective for genotyping. We selected six Japanese isolates for the determination of a nucleotide sequence that should contain the entire polyprotein-ORF. Comparison of our sequences of approximately 9 kb in length with those derived from database suggested two of our isolates (#34.G05BD and #35.CG12LC) may represent new genotypes. The #35.CG12LC isolate was particularly unique in that it had a 36-nt insertion in the NS5A region, as in the case of genotypes 2a and 2b of hepatitis C virus (HCV) having 60-nt insertion at the corresponding region. Our results also suggest that the use of single, small, subgenomic fragment for genotyping GBV-C/HGV may be misleading.
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