Abstract
The role of crowded cellular environments on biomolecular energetics and dynamcis is often only considered from an entropic point of view in the form of excluded volume effects. Here, the enthalpic contribution of dense cellular environments is considered with two different models. 1) Dense cellular environments are modeled as reduced dielectric continua. 2) Biomolecular sampling in the presence of explicit protein crowders is explored with a new coarse-grained model.
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