Abstract
The dilution enthalpies of four 2′-deoxynucleosides, namely 2′-deoxyuridine (dU), 2′-deoxycytidine (dC), 2′-deoxyguanosine (dG) and 2′-deoxythymidine (dT), in (dimethylsulfoxide (DMSO)+water) mixtures of various mass fractions (wDMSO=0 to 0.30) have been determined at T=298.15K, respectively, using an isothermal titration calorimeter (ITC200 MicroCal). On the basis of McMillan–Mayer’ theory, enthalpic pair wise self-interaction coefficients (hxx) of each compound at different values of wDMSO have been evaluated from successive dilution enthalpies. It was found that the values of hxx are all large negative and increase gradually with wDMSO across the whole composition range of the mixed solvent studied, though the degree of variation among them is somewhat different. The results indicate that (hydrophilic+hydrophilic) interactions are prevailing over (hydrophobic+hydrophobic) and (hydrophobic+hydrophilic) interactions in the ternary aqueous solutions under study.
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