Abstract
Human enteroviruses have long been associated with various diseases of man resulting into a wide range of acute symptoms involving the cardiac and skeletal muscles, central nervous system, pancreas, skin and mucous membranes. To assess the role of enteroviruses in the etiology of hypertension, DCM and HHF. We obtained stool specimens from 70 subjects comprising 65 patients and 5 controls and isolation was carried out on RD, L20B, HEp-2C and Vero cell lines and identified by neutralization with standard antisera (RIVM). Thirty-six enteroviruses were isolated and identified to be Coxsackieviruses-B5, A9, Echoviruses 1, 6, 7, 9, 11, 12, 22, 30 and Poliovirus type 1 and 3. Three most frequently occurring enterovirus serotypes which constitute 60.0% of the 30 NPEV typed and 50.0% of all the isolates were Echoviruses, Coxsackie-B5-virus and Coxsackievirus-A9. Echoviruses constituted 50.0% of all the serotypes while Coxsackieviruses-B5 and A9 accounts for the 27.8 % and 5.6% respectively. Enteroviral isolation rate was higher in age groups 51 years and above. The percentage of study subjects who had Coxsackie-B5-viruses and echoviruses was significantly (P<0.05) higher in cases of hypertension, HHF and DCM than in control subjects. Coxackie-B5-virus, Echovirus-6 and Echovirus-11 were found in both study locations. The findings of this study showed that Enteroviruses may likely be involved in the etiology of hypertension, DCM and HHF. Further studies would therefore be necessary for the prevention and control of these diseases.
Highlights
Human enteroviruses have long been associated with various diseases of man resulting into a wide range of acute symptoms involving the cardiac and skeletal muscles, central nervous system, pancreas, skin and mucous membranes[1,2]
Pauschinger et al.[20] found 24 of 94 patients with idiopathic dilated cardiomyopathy (IDCM) leading to heart failure to have either adenoviral or enteroviral polymerase chain reaction positivity from clinical heart samples
Virus isolations A total of 36 isolates belonging to 10 clearly defined enterovirus serotypes were recovered from samples collected from the subjects confirmed to be dilated cardiomyopathy (DCM) and hypertensive heart failure (HHF)
Summary
Human enteroviruses have long been associated with various diseases of man resulting into a wide range of acute symptoms involving the cardiac and skeletal muscles, central nervous system, pancreas, skin and mucous membranes[1,2] Their roles in chronic diseases such as the dilated cardiomyopathy, insulin – Enteroviruses (EVs), the Coxsackie B viruses, are cardiotropic and are important causes of myopericarditis in children and adults[10,11] and are associated with the pathogenesis of dilated cardiomyopathy[12,13]. Human enteroviruses have long been associated with various diseases of man resulting into a wide range of acute symptoms involving the cardiac and skeletal muscles, central nervous system, pancreas, skin and mucous membranes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have