Abstract
Aim: Characteristics of enterovirus infection morbidity and study of peculiarities of enterovirus circulation on some territories of Russia in 2017. Materials and methods: We investigated more than 5000 samples from the patients with enterovirus infection. The isolation and identification of enteroviruses were conducted by virological method and by partial sequencing of the genome region VP1. Phylogenic trees were constructed according to the method of Bayesian Monte Carlo Markov Chain. Results: Epidemic process and clinical picture of enterovirus infection were not the same on different territories. Peculiarities of the circulation of different types of enteroviruses on the territories were also different. In Saratov region 65% of cases were represented by enterovirus meningitis. In Murmansk region and in the Komi Republic enterovirus infection with exanthema prevailed, 95% and 60% correspondingly. In Saratov region enterovirus ECHO18 was the etiological agent of enterovirus meningitis. In Murmansk region and in the Komi Republic the cases were connected mainly with Coxsackieviruses A6. The strains of enterovirus ECHO18 were distributed to three clusters. The strains which provoked enterovirus meningitis in Saratov region belonged to cluster 3, they were formed separately from other strains of this enterovirus type and differed from the stains of ECHO18 which circulated in the North-West of Russia. The strains of Coxsackieviruses A6 identified in the North-West of Russia belonged to three sub-genotypes 5, 6, 8 of pandemic genotype of CoxsackievirusesA6. The majority of the strains belonged to sub-genotypes 6 and 8 which in 2017 dominated in the structure of Coxsackieviruses A6 in the North-West of Russia and in Russia. Conclusion: Epidemic peaks of enterovirus infection represented by different clinical forms of the disease were provoked by different types of enteroviruses. Enterovirus ECHO18 was the etiological agent of enterovirus meningitis. The main etiological factors of enterovirus infection with exanthema were Coxsackieviruses A6 of different sub-genotypes.
Highlights
Epidemic peaks of enterovirus infection represented by different clinical forms of the disease were provoked by different types of enteroviruses
Enterovirus ECHO18 was the etiological agent of enterovirus meningitis
В Саратовской области большинство случаев заболевания энтеровирусной инфекции (ЭВИ) (65%) было представлено энтеровирусным менингитом, показатель заболеваемости энтеровирусного менингита (ЭВМ) превысил среднемноголетний показатель в 4,5 раза
Summary
Epidemic peaks of enterovirus infection represented by different clinical forms of the disease were provoked by different types of enteroviruses. The main etiological factors of enterovirus infection with exanthema were Coxsackieviruses A6 of different sub-genotypes. Многообразие клинических форм энтеровирусной инфекции (ЭВИ) свидетельствует о способности энтеровирусов к репродукции в различных органах и тканях человека на основе специфического взаимодействия вирусов с рецепторами чувствительных клеток. Доля энтеровирусного менингита (ЭВМ), возбудителями которого могут быть различные энтеровирусы, значительно колебалась в разные годы. Этиологическим фактором экзантемных форм ЭВИ чаще всего являются энтеровирусы вида А: ЭВ71, Coxsackievirus А 6, А10 и А16 [5, 6]. Связанной с энтеровирусами (ЭВ), в России отмечаются в летне-осенний период, однако вспышки ЭВИ могут регистрироваться в течение всего года [1, 2, 7,8,9]. Отдельные серотипы могут доминировать в циркуляции в течение нескольких лет, затем исчезать, чтобы появиться годы спустя [3]. Цель исследования – характеристика заболеваемости энтеровирусной инфекцией и изучение особенностей циркуляции неполиомиелитных энтеровирусов на ряде территорий Российской Федерации в 2017 г
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