Enterovirus Genotype EV-104 in Humans, Italy, 2008–2009

Antonio Piralla,Fausto Baldanti,Giuseppe Gerna,Francesca Rovida

doi:10.3201/eid1606.091533

Abstract

In an epidemiologic investigation of respiratory infections in Italy, October 2008–September 2009, we tested samples from patients for respiratory viruses. Human enterovirus genotype EV-104 (identified in Switzerland) was found in 3 immunocompromised and 2 immunocompetent patients. EV-104 is closely related to human rhinoviruses; thus, both types of viruses should be sought in respiratory syndromes.

Highlights

In Switzerland during 2004–2007, a new enterovirus genotype, EV-104, was reported in association with respiratory signs and symptoms and acute otitis media in 8 children from various regions of the country [8]
The Study During an epidemiologic survey conducted from October 1, 2008, through September 30, 2009, of viral infections of the respiratory tract, in which we collected respiratory samples from all patients admitted to our University Hospital, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, we detected 5 strains of the new EV-104 genotype
Amplification products were obtained when typing was attempted by amplifying the VP4/VP2 region [14], which yielded a sequence resembling HEV-C genotypes but did not match any of the sequences published in GenBank

Summary

Introduction

In Switzerland during 2004–2007, a new enterovirus genotype, EV-104, was reported in association with respiratory signs and symptoms and acute otitis media in 8 children from various regions of the country [8]. The Study During an epidemiologic survey conducted from October 1, 2008, through September 30, 2009, of viral infections of the respiratory tract, in which we collected respiratory samples from all patients admitted to our University Hospital, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, we detected 5 strains of the new EV-104 genotype. Amplification products were obtained when typing was attempted by amplifying the VP4/VP2 region [14], which yielded a sequence resembling HEV-C genotypes but did not match any of the sequences published in GenBank.

Results

Conclusion