Abstract
Enterovirus 71 (EV71) causes life-threatening disease outbreaks in young children in Asia. This cohort study was conducted to understand the dynamics of maternal EV71 antibodies in Taiwanese young infants. Approximately 50% of neonates had detectable EV71 neutralizing antibodies, which declined to almost undetectable levels by 6 months of age.
Highlights
Enterovirus 71 (EV71) causes life-threatening disease outbreaks in young children in Asia
Vaccine development for EV71 in Taiwan should target infants. This cohort study was conducted to understand the dynamics of EV71-specific maternal antibodies in young infants in Taiwan
We found that ≈50–60% of pregnant women had serum EV71 neutralizing antibodies
Summary
Enterovirus 71 (EV71) causes life-threatening disease outbreaks in young children in Asia. This cohort study was conducted to understand the dynamics of maternal EV71 antibodies in Taiwanese young infants. EV71 has been isolated globally and causes life-threatening outbreaks in young children in Asia [4,5,6,7,8,9,10]. Vaccine development for EV71 in Taiwan should target infants This cohort study was conducted to understand the dynamics of EV71-specific maternal antibodies in young infants in Taiwan. The Study Seropositive rates of EV71 neutralizing antibodies in preschool children have been found to be higher in rural areas than in urban areas in Taiwan [11]. Serum samples were obtained from participating pregnant women and their children to measure EV71 neutralizing antibody
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