Abstract
Enterotropic mouse hepatitis virus strains (MHV-RI and MHV-Y) replicate in the intestine and rarely disseminate to other tissues, unlike respiratory MHV strains. Murine carcinoembryonic antigen-related glycoproteins (MHVR and mmCGM2) are expressed in many murine tissues and serve as receptors for respiratory MHV strains. To assess the role of receptors in the limited tissue tropism of enterotropic MHV strains, the permissiveness of MHVR- and mmCGM2-expressing cell lines and peritoneal exudate cells from BALB/c and SJL mice for MHV-RI and MHV-Y replication was determined. MHVR transfected BHK cells were susceptible to infection with both MHV-RI and MHV-Y. Additionally, the anti-MHVR monoclonal antibody CC1 blocked MHV-RI and MHV-Y infection. mmCGM2-transfected BHK cells were susceptible to infection with MHV-Y, but not MHV-RI. Peritoneal exudate cells from BALB/c mice were susceptible to infection with MHV-Y and MHVRI, whereas peritoneal exudate cells from SJL- mice were susceptible to infection with MHV-Y but not MHV-RI. These results indicate that MHV-RI probably uses a different receptor than other MHV strains to infect SJL mice and that receptors are probably not the primary determinant of the limited tissue tropism of enterotropic MHV strains.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
