Abstract
The genetic backgrounds of 24 enterotoxigenic Escherichia coli (ETEC) strains from Mexico and Guatemala expressing heat-stable toxin (ST) and coli surface antigen 6 (CS6) were analyzed. US travelers to these countries and resident children in Guatemala were infected by ETEC strains of sequence type 398, expressing STp and carrying genetically identical CS6 sequences.
Highlights
The genetic backgrounds of 24 enterotoxigenic Escherichia coli (ETEC) strains from Mexico and Guatemala expressing heat-stable toxin (ST) and coli surface antigen 6 (CS6) were analyzed
In a recent vaccine trial conducted in Mexico and Guatemala involving adult US travelers, ST-only strains expressing only CS6 and no other colonization factors (CFs) predominated among those infected with CF-positive ETEC; this toxin-CF profile (ST/CS6) was present in 35% of diarrheal cases [5]
ST-only isolates in this study showed that all STp/CS6 isolates had identical CS6 sequences to the STp/CS6 ETEC strain GB124
Summary
In a recent vaccine trial conducted in Mexico and Guatemala involving adult US travelers, ST-only strains expressing only CS6 and no other CF predominated among those infected with CF-positive ETEC; this toxin-CF profile (ST/CS6) was present in 35% of diarrheal cases [5]. Seven CS6 isolates obtained from that study, collected in the summer of 2002, were included in the present study Clinical isolates from both children and adults were shipped to Sweden, where toxin and CF profiles were confirmed as described [10]. Comparison of ETEC isolates and clinical and demographic information collected during study of US travelers to Guatemala and Mexico and resident children from Guatemala*
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