Abstract
BackgroundDiarrhea is the second most common cause of death among children less than 5 years of age worldwide. The etiological agents of diarrhea in the southeast coastal area of China were studied from July 2009 to December 2014.MethodsA total of the 2318 patients were enrolled in this study and examined for the presence of viruses, bacteria, and parasites. Multiplex real-time PCR was used for the detection of diarrheagenic Escherichia.coli (DEC). DEC strains were tested for susceptibility to a panel of 20 antibiotics using the Kirby-Bauer disc-diffusion method.ResultsOf the 2318 children with diarrhea, 962 (41.5 %) were positive for at least one pathogen. Rotavirus, human calicivirus (HucV), and DEC were predominant, with detection rates of 19.1 % (443), 17.7 % (411), and 7.6 % (177), respectively. The prevalences of various pathogens in patients of different ages and in different seasons were not the same. The resistance rates of 177 strains of DEC to ampicillin, tetracycline, and cefazolin were 93.2 %, 60.0 %, and 57.7 %, respectively.ConclusionsRotavirus, HucV, and DEC were the main pathogens associated with diarrhea in Zhejiang, China. DEC possessed high levels of antibiotic resistance. Increased monitoring of etiological agents of diarrhea is necessary.
Highlights
Diarrhea is the second most common cause of death among children less than 5 years of age worldwide
We found that the detection rate of rotavirus was higher in children under the age of 3 than in children of other ages and that it was higher in winter than in other seasons, which is consistent with other reports [15, 17, 18]
We found that the detection rate of norovirus exhibited a seasonal trend; detection rates in the winter and spring were significantly higher than those in the summer and autumn, which is consistent with other reports [23, 24]
Summary
Diarrhea is the second most common cause of death among children less than 5 years of age worldwide. The etiological agents of diarrhea in the southeast coastal area of China were studied from July 2009 to December 2014. Diarrhea is a maior cause of death in children under 5 years of age worldwide, with an estimated 1.5 million deaths per year. Diarrhea is caused mainly by enteric pathogens, including viruses, bacteria, The People’s Republic of China (PRC) is located in the eastern part of Asia, facing the Pacific Ocean on the east and encompassing temperate and tropical zones. Diarrhea is one of the main life-threatening diseases in china. The southeast coast of China had a population of approximately 54 million and a stable annual birth rate of 500,000. An epidemiological study of an infectious disease in a community is an initial step
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